Basic Information
VIS ID
TVIS30014293
Fusion event
HIV-HEMK1 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
50615254/50577823 (Hg38)
End
50615254/50577823 (Hg38)
Orient
-
Location type
Intronic
Target gene
HEMK1
miRNAs that regulate target gene
hsa-mir-6803-5p ; hsa-mir-6751-5p ; hsa-mir-4472 ; hsa-mir-4447 ; hsa-mir-92a-2-5p ; hsa-mir-7110-5p ; hsa-mir-6881-5p ; hsa-mir-6842-5p ; hsa-mir-6752-5p ; hsa-mir-6835-5p ; hsa-mir-548p ; hsa-mir-3653-3p ; hsa-mir-505-5p ; hsa-mir-3185 ; hsa-mir-4311 ; hsa-mir-186-5p
Nearest miRNA
hsa-mir-12127/Upstream/304526; hsa-let-7g/Downstream/97257;
Nearest TSS
ENST00000440867/Upstream/699; ENST00000486712/Downstream/23325;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/8282, chr3-CpG: 91/Downstream/33685
Upstream sequence
AGTATCTTGCCAGTCCAAGAAGGGTTGACTATAAGACCTCATTCTTGTAGTGAAGGGTAGGGGTCTGCCCCCGTGCCTACCCCTTTCTCCCTGTCTGTGT
Downstream sequence
AGGCTTCGGTTGCAGGACAGGATTTGGATCATCCACCTCGACATGACCTCAGGTACCCTCCCCTGCATGTTCCTTGAGAGAGGGAGACTAGATGCAGGTG
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
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