Basic Information
VIS ID
TVIS30014312
Fusion event
HIV-KDM3A integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
86713791/86486668 (Hg38)
End
86713791/86486668 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2L
Target gene
KDM3A
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-92b-3p ; hsa-mir-627-5p ; hsa-mir-30e-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/293560; hsa-mir-10b/Downstream/708118;
Nearest TSS
ENST00000437798/Upstream/1987; ENST00000483866/Downstream/260;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/44344, chr2-CpG: 60/Downstream/76183
Nearest cancer related gene
KDM3A(TSG, No orient, 0)
Upstream sequence
TATTTGGCCCCTACTTTTCCAGTCCTCCTGGAAATTACTTATTTCTTCCTGCCATAATTACTTCCATGTCATTTTCCATTTCTAGCCTTAGACCTGTGGG
Downstream sequence
TGTCTTTCTCAAAAAGGACAAGGTCTGTTGTTGTCTTCGCTATGTTCTCCAAAGACTGTTGGGGGAGGGAAGGGAAGGAGGGGCAAGGACTCCAGCCCCA
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
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