Basic Information
VIS ID
TVIS30014339
Fusion event
HIV-NUMA1 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
71742451/72031405 (Hg38)
End
71742451/72031405 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
NUMA1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1208 ; hsa-mir-1252-5p ; hsa-mir-1911-3p ; hsa-mir-1972 ; hsa-mir-211-3p ; hsa-mir-4466 ; hsa-mir-4767 ; hsa-mir-6721-5p ; hsa-mir-6753-5p ; hsa-mir-675-5p ; hsa-mir-6760-3p ; hsa-mir-6816-3p ; hsa-mir-7112-3p ; hsa-mir-7112-5p ; hsa-mir-7113-5p
Nearest miRNA
hsa-mir-10392/Upstream/557837; hsa-let-7a-2/Downstream/40823;
Nearest TSS
ENST00000527297/Upstream/6555; ENST00000537483/Downstream/4582;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/217598, chr11-CpG: 51/Downstream/48934
Upstream sequence
agaaaaaagaaaaactaataaacataaagcactattatGGTTAATAAAATTAAAATAATGAAGTAGACATAACATTTGTATTTCTTAATAGTTAAGTTAG
Downstream sequence
CTGCATGCACTATAGAATTAAGAGGATTTTTAAAAATCAATGATTTCTCTACAGACATGATAGTATTTATTTGAGTTAAACACTTTCACATTTAAAAACA
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
Curate