Basic Information
VIS ID
TVIS30014345
Fusion event
HIV-NFU1 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
69645923/69418791 (Hg38)
End
69645923/69418791 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
NFU1
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-99a-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-1301/Upstream/315036; hsa-mir-10b/Downstream/834127;
Nearest TSS
ENST00000437798/Upstream/2587; ENST00000418066/Downstream/18604;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/31307, chr2-CpG: 51/Downstream/18368
Upstream sequence
atctcctgacctcatgatctgcccacctcggcctcccaaagtgctgggattacaggcgtgagccaccacacccggccCCCAGTATGTCCACTTTTAAGGA
Downstream sequence
CATAAAGAGCTCAGACTAATCCTTTCAATTTGCTTAAGGGGAGTTTAATAAATATTTTTGATTTTCACACACTATCAGGCAAGTGATTTAAGTTCCGTGG
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
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