Basic Information
VIS ID
TVIS30014362
Fusion event
HIV-SF3B2 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
65823773/66056302 (Hg38)
End
65823773/66056302 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
SF3B2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-877-3p ; hsa-mir-93-3p ; hsa-mir-615-3p ; hsa-mir-18a-3p ; hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-324-5p ; hsa-mir-331-3p ; hsa-mir-342-3p ; hsa-mir-3189-3p
Nearest miRNA
hsa-mir-10392/Upstream/407049; hsa-let-7a-2/Downstream/878132;
Nearest TSS
ENST00000527297/Upstream/1009; ENST00000525207/Downstream/968;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/3549, chr11-CpG: 139/Downstream/13481
Upstream sequence
accagcctggccaacataatgaaaccctgtctctcagaaatacaaaaattagccaggtgtggcggcgcatgcctgtagtcccagctacttgggaggctga
Downstream sequence
ggtgggaggatggcttgagctggggaggccgaggttgcagtgagctgagatcatgccactgtactccagcctaggcaacagagccagactctgtctcaaa
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
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