Basic Information
VIS ID
TVIS30014371
Fusion event
HIV-NF1 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
29573450/31246432 (Hg38)
End
29573450/31246432 (Hg38)
Orient
+
Location type
Intronic
Target gene
NF1
miRNAs that regulate target gene
hsa-mir-10b-5p ; hsa-mir-370-3p ; hsa-mir-20a-3p ; hsa-mir-193b-3p ; hsa-let-7e-5p ; hsa-mir-9-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-193a-3p ; hsa-mir-374a-5p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-107 ; hsa-mir-514a-5p
Nearest miRNA
hsa-mir-1180/Upstream/152007; hsa-mir-10226/Downstream/288451;
Nearest TSS
ENST00000595228/Upstream/13402; ENST00000581113/Downstream/27190;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/150972, chr17-CpG: 29/Downstream/98885
Nearest cancer related gene
NF1(TSG, No orient, 0)
Upstream sequence
TCTTGCTTTGCAGTCCATGCTAATTTCTGAACTCTTACTGTATTCATATGCTGTGCCACACAGCAAACTCTAAGGAATCTACAGCAATGACGTAAGTGTC
Downstream sequence
CAAAGCATTTCTGTAATACGTTAATTAATATAGAAACAAAATTACTAATTAACCTGTTAAAaacaaatatttactcagtacttgctgtggtaaggcactg
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
Curate