Basic Information
VIS ID
TVIS30014387
Fusion event
HIV-FBRSL1 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
133091037/132514451 (Hg38)
End
133091037/132514451 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
FBRSL1
miRNAs that regulate target gene
hsa-mir-423-3p ; hsa-mir-147a ; hsa-mir-2113 ; hsa-mir-34a-3p ; hsa-mir-4519 ; hsa-mir-4668-3p ; hsa-mir-5010-3p ; hsa-mir-574-5p ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-8062
Nearest miRNA
hsa-let-7i/Upstream/4220273; hsa-mir-6763/Downstream/67546;
Nearest TSS
ENST00000382841/Upstream/7421; ENST00000543360/Downstream/45596;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/5677, chr12-CpG: 31/Downstream/11225
Upstream sequence
CGGCCTGACCCAGGATCTCTCTGGCCTCCCTGGCGTCTTCCCAGGTGGCCCAGGACCGCAGTACCAGACTGAGCTGGACTGGCATTGACCAGGCCGAGGC
Downstream sequence
CACCGGCCATCCTCCTCCGGCCAGAAGCTGCAGTGATAGGGGACATCCCTAGCAGTTCACAAAGCTGTGGGGAGACCCCGAGGGGGAAGGGTTTCCATGC
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
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