Basic Information
VIS ID
TVIS30014393
Fusion event
HIV-ZNF251 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
145975693/144750308 (Hg38)
End
145975693/144750308 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
ZNF251
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1233-5p ; hsa-mir-1298-3p ; hsa-mir-185-5p ; hsa-mir-30c-1-3p ; hsa-mir-30c-2-3p ; hsa-mir-3165 ; hsa-mir-4306 ; hsa-mir-452-3p ; hsa-mir-4644 ; hsa-mir-4667-5p ; hsa-mir-4700-5p ; hsa-mir-5192 ; hsa-mir-541-3p ; hsa-mir-6134 ; hsa-mir-637 ; hsa-mir-654-5p ; hsa-mir-6731-5p ; hsa-mir-6751-5p ; hsa-mir-6752-5p ; hsa-mir-6769a-5p ; hsa-mir-6769b-5p ; hsa-mir-6778-5p ; hsa-mir-6788-5p ; hsa-mir-6803-5p ; hsa-mir-6835-5p ; hsa-mir-6842-5p ; hsa-mir-6878-5p ; hsa-mir-6880-5p ; hsa-mir-7110-5p ; hsa-mir-7155-5p ; hsa-mir-8071 ; hsa-mir-8085 ; hsa-mir-8089 ; hsa-mir-92a-2-5p
Nearest miRNA
hsa-mir-10400/Upstream/287769; hsa-mir-6850/Downstream/41623;
Nearest TSS
ENST00000518652/Upstream/36409; ENST00000528012/Downstream/5133;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/19704, chr8-CpG: 72/Downstream/4839
Upstream sequence
gtatgctttgtaattttctgttgataggtagacatgatacactgggtaaaaggaattgcagtaaacagggctttcatcctgttttcaggtgttggggtgg
Downstream sequence
gaaagtgttctatgatactatgagcagggctcagtcttgctgagcttgtgtccctggactatgaacttcccaagtgcttttcagcttcccccacctgcca
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
Curate