Basic Information
VIS ID
TVIS30014404
Fusion event
HIV-MPZL3 integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
118117514/118246799 (Hg38)
End
118117514/118246799 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11B
Target gene
MPZL3
miRNAs that regulate target gene
hsa-mir-4436b-5p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-671-5p ; hsa-mir-4729 ; hsa-mir-4786-3p ; hsa-mir-449b-3p ; hsa-mir-1228-3p ; hsa-mir-1273g-3p ; hsa-mir-1827 ; hsa-mir-1910-3p ; hsa-mir-2467-3p ; hsa-mir-3612 ; hsa-mir-377-5p ; hsa-mir-4257 ; hsa-mir-4459 ; hsa-mir-455-3p ; hsa-mir-4695-5p ; hsa-mir-4793-3p ; hsa-mir-508-5p ; hsa-mir-6086 ; hsa-mir-6499-3p ; hsa-mir-650 ; hsa-mir-6511a-5p ; hsa-mir-6516-5p ; hsa-mir-665 ; hsa-mir-6807-5p ; hsa-mir-766-3p ; hsa-mir-7703
Nearest miRNA
hsa-mir-10392/Upstream/4796711; hsa-let-7a-2/Downstream/397201;
Nearest TSS
ENST00000527297/Upstream/21705; ENST00000529713/Downstream/5521;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/93320, chr11-CpG: 22/Downstream/112650
Upstream sequence
tcagcctcccaaatagctgagaccacaggcgtgtgccaccacacctggctaattttttgtatttttggtagagacggggtttccctatgttgcctagtct
Downstream sequence
ggactcaaactcctgaactcaggcaatcctcccatctcaacctctcaaagtgctgggattacaggcgtgagccaccatgcttagcctaggccacttttcg
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
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