Basic Information
VIS ID
TVIS30014412
Fusion event
HIV-UBE3C integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q36.3
Reference genome
GRCh37/hg19
Start
156949548/157156854 (Hg38)
End
156949548/157156854 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
UBE3C
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-7-5p ; hsa-mir-26b-5p ; hsa-let-7g-5p ; hsa-mir-10a-5p ; hsa-mir-30c-5p ; hsa-mir-17-5p ; hsa-let-7a-5p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-30a-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-136-3p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-4668-5p ; hsa-mir-4297 ; hsa-mir-5581-5p ; hsa-mir-922 ; hsa-mir-3714 ; hsa-mir-532-5p ; hsa-mir-548an
Nearest miRNA
hsa-mir-10399/Upstream/5723215; hsa-mir-153-2/Downstream/417482;
Nearest TSS
ENST00000635602/Upstream/17575; ENST00000469336/Downstream/50659;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/17188, chr7-CpG: 106/Downstream/122254
Nearest cancer related gene
UBE3C(OG, No orient, 0)
Upstream sequence
ATTGCTGTACTTCTCCTGTCCCCCTTAATAATACTCTCGGAGACAGTTCCTGATCAGTAGATAGATCTACCACATTCCTTTAAAGAGCTATATGATATTC
Downstream sequence
CATGTAGTGAATGCCCTATAATTTTCAGCAGCCAAAAAAATAAAGCTGACTCCAGTGAGTTATTAATGTGGTCCTTATTATATGTGAAGACAGCCTTATT
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
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