Basic Information
VIS ID
TVIS30014441
Fusion event
HIV-C2CD2L integration
Validated
Yes
Detection method
invPCR
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2007
PubMed ID
17262715
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
118981923/119111213 (Hg38)
End
118981923/119111213 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11B
Target gene
C2CD2L
miRNAs that regulate target gene
hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6818-3p ; hsa-mir-3191-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-6823-3p ; hsa-mir-2114-3p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6728-3p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-6748-3p ; hsa-mir-660-3p ; hsa-mir-1-5p ; hsa-mir-501-5p ; hsa-mir-508-5p ; hsa-mir-3145-5p ; hsa-mir-27a-3p ; hsa-mir-27b-3p
Nearest miRNA
hsa-mir-10392/Upstream/200426; hsa-let-7a-2/Downstream/201737;
Nearest TSS
ENST00000527297/Upstream/156; ENST00000533458/Downstream/348;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/3138, chr11-CpG: 72/Downstream/9963
Upstream sequence
CACCCAGCCAGCCATGATGGTCAACCTCAGGGCTTGCTCTGCCCCAGGAGGCCTGGTGAGTTGGCACCCAAAGCAAAAGATTTGCATGCACCTTGTTCCT
Downstream sequence
AGGGTGCTATGTCAGGATTCTTGCTCTTTGGACCTTCTTCTGCTCTTAGGTACCCAGTGAGAAGCCACCCATGATGCCCCAGGCTCAGCCAGCCATCCCC
Reference
Ikeda, T., et al. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis,2007, 195(5): 716-725.
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