Basic Information
VIS ID
TVIS30014446
Fusion event
HIV-MIB2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.33
Reference genome
GRCh37/hg19
Start
1549332/1613952 (Hg38)
End
1549182/1613952 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
MIB2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-423-3p ; hsa-mir-4697-5p ; hsa-mir-4488 ; hsa-mir-1237-5p ; hsa-mir-3195 ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-6886-5p ; hsa-mir-6798-5p ; hsa-mir-4787-3p ; hsa-mir-6805-5p
Nearest miRNA
hsa-mir-12136/Upstream/274244; hsa-mir-101-1/Downstream/1514023;
Nearest TSS
ENST00000473358/Upstream/13856; ENST00000463492/Downstream/1463;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/13196, chr1-CpG: 176/Downstream/1121
Nearby gene
MIB2(No orient, 1462)
Upstream sequence
ctcgagataagagctgtgcagccgggtcaggaagtgatcggtctaggtcggaacaggagaatcagttagacacaacggatgtgtttgagcctttggaaaa
Downstream sequence
cggtatcgttaggcatgtggcgaaaacgttggggtacttgaaaaaaaggctggccatgggttagtaaaaagctagatatgtgaaaatattaggtaattat
Target sequence
caagaaaggagacagacaaagtgagtctcaaggatgagagcagagaaaagctcgagataagagctgtgcagccgggtcaggaagtgatcggtctaggtcggaacaggagaatcagttagacacaacggatgtgtttgagcctttggaaaa
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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