Basic Information
VIS ID
TVIS30014449
Fusion event
HIV-GNB1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.33
Reference genome
GRCh37/hg19
Start
1809470/1878031 (Hg38)
End
1809358/1878031 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
GNB1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-103a-3p ; hsa-mir-101-3p ; hsa-mir-16-5p ; hsa-mir-589-3p ; hsa-mir-106a-5p ; hsa-mir-17-5p ; hsa-let-7b-5p ; hsa-mir-218-5p ; hsa-mir-493-3p ; hsa-mir-3064-3p ; hsa-mir-3138 ; hsa-mir-1227-3p ; hsa-mir-891a-5p ; hsa-mir-4795-5p ; hsa-mir-6838-5p ; hsa-mir-6501-3p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-2278 ; hsa-mir-582-5p ; hsa-mir-889-3p ; hsa-mir-324-5p ; hsa-mir-302a-5p ; hsa-mir-1277-5p ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-5692a ; hsa-mir-4520-3p ; hsa-mir-874-5p ; hsa-mir-4533 ; hsa-mir-1252-5p ; hsa-mir-6125 ; hsa-mir-3120-3p ; hsa-mir-1287-5p ; hsa-mir-2392 ; hsa-mir-3135b ; hsa-mir-3907 ; hsa-mir-3928-3p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4524b-3p ; hsa-mir-4768-3p ; hsa-mir-766-5p
Nearest miRNA
hsa-mir-12136/Upstream/538323; hsa-mir-101-1/Downstream/1249944;
Nearest TSS
ENST00000473358/Upstream/45746; ENST00000412228/Downstream/12370;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/95329, chr1-CpG: 199/Downstream/11935
Upstream sequence
CCTTTTACTAACATAGGAAGAGGCAAATGCAGACACAGAAGTCTTCTCAGATGAATGAGGAGAAAGAGCTCACACCAGCAGGTCTATAATGCATAGGCTC
Downstream sequence
CAGGAGCAATGACCCAAGAACTAAGTTCACtgtcaccacggccaactgtctaatctccctgtagatccagtcatctgtaagatggagctattaacagcac
Target sequence
TGGAAAAATGTTCCTTTTACTAACATAGGAAGAGGCAAATGCAGACACAGAAGTCTTCTCAGATGAATGAGGAGAAAGAGCTCACACCAGCAGGTCTATAATGCATAGGCTC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate