Basic Information
VIS ID
TVIS30014450
Fusion event
HIV-PLCH2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.32
Reference genome
GRCh37/hg19
Start
2385745/2454306 (Hg38)
End
2385892/2454306 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
PLCH2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-331-3p
Nearest miRNA
hsa-mir-12136/Upstream/1114598; hsa-mir-101-1/Downstream/673669;
Nearest TSS
ENST00000473358/Upstream/28326; ENST00000278878/Downstream/13153;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/9931, chr1-CpG: 30/Downstream/1924
Nearby gene
PLCH2(No orient, 22008)
Upstream sequence
CCTTCCTGCCCTGCAGCACTGGAGGTGACCTGGGCCTGGGCCCTCCAGTTCCCCGATGGCCAGTGCCCCGCCCACCATGCCCGACTCACCCTGACACGTG
Downstream sequence
TGGTCCCCTCCGGGAGGATGGTCTGTGGAGGCTCAAGGCCATGGACCTGCTACTCCCCAGGGGCTGAACCAGCAATGCACCGAGTGGACCGTGTCCCTTT
Target sequence
GGGATCCCCAGGCAGCCCCGAGACAGGGTCTTAGGGCTGCCTCTGCAGGACCCTTGGAAGTGCAGGCCCTTGCTCAGGAAGGGGTTGATGGTGTGGTATGGCAGGAGGCGGCACCACGTGACATGCTTGATGTGACATGATGTGGTG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate