Basic Information
VIS ID
TVIS30014452
Fusion event
HIV-TNFRSF9 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.23
Reference genome
GRCh37/hg19
Start
7979076/7919016 (Hg38)
End
7979019/7919016 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA1A
Target gene
TNFRSF9
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-374a-3p ; hsa-mir-3140-3p ; hsa-mir-4267 ; hsa-mir-4733-3p ; hsa-mir-1226-3p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-627-3p ; hsa-mir-4762-5p ; hsa-mir-203a-3p ; hsa-mir-3613-3p
Nearest miRNA
hsa-mir-12136/Upstream/1489120; hsa-mir-101-1/Downstream/947486;
Nearest TSS
ENST00000473358/Upstream/65504; ENST00000460192/Downstream/16084;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/91600, chr1-CpG: 31/Downstream/23332
Upstream sequence
attagaacagccactttgaaaagcaatttggtactgcagtagaCTATTGTTCAGAAATATCTTCTCCTCACCCCTATTTACAGAATATACTTTTCTGCCC
Downstream sequence
TATTGATGCCTGGCTTGGCTGCAGGATTTGCTCTAAAGGTTATAGTAGAACCAACTAAATAGGAGCAGAAGTGACAGATACccatttgccatgcgatggc
Target sequence
CTATTGTTCAGAAATATCTTCTCCTCACCCCTATTTACAGAATATACTTTTCTGCCC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate