Basic Information
VIS ID
TVIS30014453
Fusion event
HIV-RERE integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.23
Reference genome
GRCh37/hg19
Start
8538850/8478790 (Hg38)
End
8538922/8478790 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
RERE
miRNAs that regulate target gene
hsa-mir-200b-3p ; hsa-mir-429 ; hsa-mir-92b-3p ; hsa-mir-301a-3p ; hsa-mir-320a ; hsa-mir-4681 ; hsa-mir-4722-3p ; hsa-mir-4763-5p ; hsa-mir-4769-3p ; hsa-mir-596 ; hsa-mir-6501-3p ; hsa-mir-6727-3p ; hsa-mir-6817-5p
Nearest miRNA
hsa-mir-12136/Upstream/2048894; hsa-mir-101-1/Downstream/387712;
Nearest TSS
ENST00000473358/Upstream/53152; ENST00000442636/Downstream/47149;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/54511, chr1-CpG: 69/Downstream/224156
Nearby gene
RERE(No orient, 55103)
Nearest cancer related gene
RERE(OG, No orient, 0)
Upstream sequence
AGACTTGAAAAAGCTACAGCTTCAAGGATTGCCTGAGTTTATCCCAGGCCAGCTCAAAGACCAACCTTAAAACAACACAACTTGCCCACAAGGGTCACTA
Downstream sequence
GCTAGGGTAGTGGCTGAGGAAGAAACAACCTGGGAGGTCAGAACATATCAATTAATATGGTAGTTATACATGACAATTTTGTTATCTAAATAAATATCCT
Target sequence
ATGAGCAACACCTTCCCTACTCTATCAGGCCCAGGCTAGGACTGGTGCAGGCTGGACCCAGAGTTTTGAGGG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate