Basic Information
VIS ID
TVIS30014455
Fusion event
HIV-RERE integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.23
Reference genome
GRCh37/hg19
Start
8780529/8720470 (Hg38)
End
8780427/8720470 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
RERE
miRNAs that regulate target gene
hsa-mir-200b-3p ; hsa-mir-429 ; hsa-mir-92b-3p ; hsa-mir-301a-3p ; hsa-mir-320a ; hsa-mir-4681 ; hsa-mir-4722-3p ; hsa-mir-4763-5p ; hsa-mir-4769-3p ; hsa-mir-596 ; hsa-mir-6501-3p ; hsa-mir-6727-3p ; hsa-mir-6817-5p
Nearest miRNA
hsa-mir-12136/Upstream/2290574; hsa-mir-101-1/Downstream/146032;
Nearest TSS
ENST00000473358/Upstream/17251; ENST00000442636/Downstream/33368;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/16949, chr1-CpG: 100/Downstream/96483
Nearby gene
ENO1(No orient, 140529)
Nearest cancer related gene
RERE(OG, No orient, 0)
Upstream sequence
caataaccaacagatttttttgtattctataaatttcacacaatattcaaaggcagtaagtgctaagaaaaaaaagtagagcaagaaggatTAAACATAT
Downstream sequence
GCAGAGGGTAGGTACCAGCTGgagagagaagagagacagacagacagagtcagagagagagcaagagagagagagagaacaagaacgagcaagagagagc
Target sequence
aacaataaccaacagatttttttgtattctataaatttcacacaatattcaaaggcagtaagtgctaagaaaaaaaagtagagcaagaaggatTAAACATAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate