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Viral Integration Site DataBase
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TVIS30014457
Basic Information
VIS ID
TVIS30014457
Fusion event
HIV-UBE4B integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.22
Reference genome
GRCh37/hg19
Start
10140487/10080429 (Hg38)
End
10140682/10080429 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
UBE4B
miRNAs that regulate target gene
hsa-mir-335-5p
;
hsa-mir-423-3p
;
hsa-mir-92a-3p
;
hsa-mir-6885-3p
;
hsa-mir-3926
;
hsa-mir-1251-3p
;
hsa-mir-4753-5p
;
hsa-mir-9-5p
;
hsa-mir-7111-5p
;
hsa-mir-5698
;
hsa-mir-6870-5p
;
hsa-mir-4723-5p
;
hsa-mir-3175
;
hsa-mir-8085
;
hsa-mir-6731-5p
;
hsa-mir-4668-5p
;
hsa-mir-3202
;
hsa-mir-3148
;
hsa-mir-3179
;
hsa-mir-873-5p
;
hsa-mir-1182
;
hsa-mir-1178-5p
;
hsa-mir-6794-5p
;
hsa-mir-4716-3p
;
hsa-mir-6783-5p
;
hsa-mir-6876-5p
;
hsa-mir-4476
;
hsa-mir-2681-5p
;
hsa-mir-607
;
hsa-mir-29b-2-5p
;
hsa-mir-580-3p
;
hsa-mir-3671
;
hsa-mir-584-5p
;
hsa-mir-6798-3p
;
hsa-mir-186-3p
;
hsa-mir-4762-5p
;
hsa-mir-758-5p
;
hsa-mir-218-2-3p
;
hsa-mir-501-5p
;
hsa-mir-500a-5p
;
hsa-mir-651-3p
Nearest miRNA
hsa-mir-12136/Upstream/112971; hsa-mir-101-1/Downstream/1948729;
Nearest TSS
ENST00000473358/Upstream/46833;
ENST00000462658/Downstream/20432;
Nearest CpG islands
None/Target,
chr1-CpG: 111/Upstream/47083
,
chr1-CpG: 156/Downstream/129528
Nearest cancer related gene
UBE4B
(TSG, No orient, 0)
Upstream sequence
gaatcgcttgaacccaggaggcagaggttgcagtgagccaagatcccaccactgcactccagtgtggtgagagtgagaatccatctcaaaaaaaaaaaaa
Downstream sequence
ttattccaaatagccaagatatggaagcaacctaaataatccatcttcagatgaatgggaaaagaaactgtggtatgtatccacaatggaatattattca
Target sequence
gaaagaaagaaagaaaGAAAATTCTAtgttggtgagagtgtaaatttatatagccattttacaaaacaatatggaggtccctcagaaaactaaaaacagagctaccatatgatctggcagtcccactgagtatatatccaaagaaattaagattcatatgctgaagagatacctctactcatgttcattgcagca
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT1
Sample type
PBMC
Age
47
Gender
Male
CpG Island Information
×
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