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Viral Integration Site DataBase
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TVIS30014458
Basic Information
VIS ID
TVIS30014458
Fusion event
HIV-KIF1B integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.22
Reference genome
GRCh37/hg19
Start
10415716/10355658 (Hg38)
End
10415420/10355658 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
KIF1B
miRNAs that regulate target gene
hsa-mir-193b-3p
;
hsa-mir-9-5p
;
hsa-mir-124-3p
;
hsa-mir-26b-5p
;
hsa-mir-16-5p
;
hsa-mir-27b-3p
;
hsa-let-7c-5p
;
hsa-mir-32-5p
;
hsa-mir-92a-3p
;
hsa-mir-92b-3p
;
hsa-mir-214-3p
;
hsa-mir-511-5p
;
hsa-mir-6755-3p
;
hsa-mir-431-5p
;
hsa-mir-567
;
hsa-mir-4635
;
hsa-mir-4781-3p
;
hsa-mir-548l
;
hsa-mir-548n
;
hsa-mir-4762-3p
;
hsa-mir-4303
;
hsa-mir-4795-3p
;
hsa-mir-1827
;
hsa-mir-7162-3p
;
hsa-mir-4649-3p
;
hsa-mir-126-5p
;
hsa-mir-6511a-5p
;
hsa-mir-1910-3p
;
hsa-mir-5096
;
hsa-mir-6848-3p
;
hsa-mir-6843-3p
;
hsa-mir-3187-3p
;
hsa-mir-4435
;
hsa-mir-588
;
hsa-mir-4701-5p
;
hsa-mir-548s
;
hsa-mir-4256
;
hsa-mir-197-3p
;
hsa-mir-4755-3p
;
hsa-mir-6131
;
hsa-mir-6821-3p
;
hsa-mir-3663-5p
;
hsa-mir-6790-3p
;
hsa-mir-4750-3p
;
hsa-mir-372-5p
;
hsa-mir-371a-5p
;
hsa-mir-616-5p
;
hsa-mir-373-5p
;
hsa-mir-371b-5p
;
hsa-mir-4716-5p
;
hsa-mir-29b-3p
;
hsa-mir-4455
;
hsa-mir-548ac
;
hsa-mir-548ae-3p
;
hsa-mir-548ah-3p
;
hsa-mir-548aj-3p
;
hsa-mir-548am-3p
;
hsa-mir-548aq-3p
;
hsa-mir-548bb-3p
;
hsa-mir-548d-3p
;
hsa-mir-548h-3p
;
hsa-mir-548j-3p
;
hsa-mir-548x-3p
;
hsa-mir-548z
;
hsa-mir-574-5p
;
hsa-mir-6867-5p
Nearest miRNA
hsa-mir-12136/Upstream/388200; hsa-mir-101-1/Downstream/1673500;
Nearest TSS
ENST00000473358/Upstream/2994;
ENST00000470616/Downstream/9508;
Nearest CpG islands
None/Target,
chr1-CpG: 111/Upstream/29326
,
chr1-CpG: 147/Downstream/42833
Nearest cancer related gene
KIF1B
(TSG, No orient, 0)
Upstream sequence
CTTAAATGATTTTTAGAGTTTCAAATTATTTTTTCATTCCATTTGCTAAACTTGTCAGTTTTATTCTTAGACTCTTTCAAGTTTTCCTCTTCTACATTAC
Downstream sequence
AAAGTAGAATGTTTCTCCCTTCATTTCATACAGAATCTCAGGTTTTGTTTTCTGTTTTCCTCTTTATCTGTCTTCTCTCCGTCAAAAGCATGAAGGGTTT
Target sequence
TTTGCAGGCTCTTTCTTGATAAGGATATTCCTAGGTATTGTCTGTTTGCTTTTTTGCACGTAGGATTCTAGTTTATCAGAATGCTTTCTGTCTTATGTTGCTTTGCCATTTTAATTTTGTAGTCCCCTCCCCATGTAAACCTACTGTACCTAGGATAGAGTAGACCCTGTTCTGTACCCTAAGAAGCGTATAGCTTCTTAAATGATTTTTAGAGTTTCAAATTATTTTTTCATTCCATTTGCTAAACTTGTCAGT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT1
Sample type
PBMC
Age
47
Gender
Male
CpG Island Information
×
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