Basic Information
VIS ID
TVIS30014459
Fusion event
HIV-DHRS3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.21
Reference genome
GRCh37/hg19
Start
12669246/12609241 (Hg38)
End
12669327/12609241 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
DHRS3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-92a-3p ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-130b-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-4719
Nearest miRNA
hsa-mir-12136/Upstream/30218; hsa-mir-101-1/Downstream/4249708;
Nearest TSS
ENST00000473358/Upstream/12933; ENST00000376221/Downstream/7455;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/13006, chr1-CpG: 124/Downstream/7737
Upstream sequence
TTCCACAGTGTTAGGAGATTTTTCAGTCTGGGGATGGTGGtcactccaagaacactaagtgtcacaaggagagaaccttgtttatgaggttccctgccgc
Downstream sequence
GTTGTCACTTCCTCACCTAAGTTACCAGCAAGAAAGATCAGGATCTGGCTGGGAGCAGGGCTGCCCAGCAGAGCCCTGAGGGCTGGGTGCCAGCTGCCTC
Target sequence
atctccaaggcctagTTTGCTGAATCAATGAACAGAGCCAACATAGTCACGATTCCTCAGAGCCGTGTCACCCTGAAGCTG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate