Basic Information
VIS ID
TVIS30014465
Fusion event
HIV-SPEN integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.13
Reference genome
GRCh37/hg19
Start
16263305/15936810 (Hg38)
End
16263254/15936810 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
SPEN
miRNAs that regulate target gene
hsa-mir-151a-5p ; hsa-mir-877-3p ; hsa-mir-23b-5p ; hsa-mir-769-5p ; hsa-mir-615-3p ; hsa-mir-193b-3p ; hsa-mir-423-3p ; hsa-mir-324-5p ; hsa-mir-331-3p ; hsa-mir-328-3p ; hsa-mir-106b-5p ; hsa-mir-320a ; hsa-mir-186-5p ; hsa-mir-125b-5p ; hsa-mir-196a-5p ; hsa-mir-92a-3p ; hsa-mir-16-5p ; hsa-mir-18a-5p ; hsa-mir-18b-5p ; hsa-mir-214-3p ; hsa-mir-3619-5p ; hsa-mir-4722-5p ; hsa-mir-4735-3p ; hsa-mir-4768-3p ; hsa-mir-6165 ; hsa-mir-761 ; hsa-mir-885-3p
Nearest miRNA
hsa-mir-12136/Upstream/3357787; hsa-mir-101-1/Downstream/922139;
Nearest TSS
ENST00000473358/Upstream/60234; ENST00000487496/Downstream/1773;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/2150, chr1-CpG: 28/Downstream/6595
Upstream sequence
cagatcacttgaggtcaggagttcaagaccagcttggccaacatggtgaaactctgtccctacttaaaGAAAAAGAAATCCGCCTTTTGGTAAAGATAGT
Downstream sequence
GGTTGAGTACAAGTGAACTGGTCAGCTAGTCCCTAAAGATGTTGATCTTTTCATGAGTTTAAAGAGCTTTCTTAGTTCTGAGATGAAAGTATTAGATCAC
Target sequence
aactctgtccctacttaaaGAAAAAGAAATCCGCCTTTTGGTAAAGATAGT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate