Basic Information
VIS ID
TVIS30014468
Fusion event
HIV-TMCO4 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.13
Reference genome
GRCh37/hg19
Start
20072945/19746452 (Hg38)
End
20072793/19746452 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
TMCO4
miRNAs that regulate target gene
hsa-mir-615-3p
Nearest miRNA
hsa-mir-12136/Upstream/849304; hsa-mir-101-1/Downstream/887227;
Nearest TSS
ENST00000473358/Upstream/8033; ENST00000454736/Downstream/24975;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/67080, chr1-CpG: 26/Downstream/53577
Upstream sequence
TCCCAGGGAGTCACTGCTGGTGAGGATCCAGGCATGTCCTTTTAGGAACTGGGCCACCCTGGCTGAAAATTCCTCTGAACCCATCATTCCTTTTGAACCT
Downstream sequence
TACCTGTCAGGCCAGCTCCAGCTGCACCAAACAGCGAGGTCATGATGGCTATGCCGGCTGCTGAGCCCAGAGCCGCTGCCCCGGCGCTGCCAATAATCGT
Target sequence
GAGCTCTGGGAAGGCTGGGACCCAGAGTGAGAAAAGCCACGTCTCCTCTGTCTCCCAGGGAGTCACTGCTGGTGAGGATCCAGGCATGTCCTTTTAGGAACTGGGCCACCCTGGCTGAAAATTCCTCTGAACCCATCATTCCTTTTGAACCT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate