Basic Information
VIS ID
TVIS30014475
Fusion event
HIV-CDC42 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.12
Reference genome
GRCh37/hg19
Start
22384661/22058168 (Hg38)
End
22384692/22058168 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
CDC42
miRNAs that regulate target gene
hsa-mir-133a-3p ; hsa-mir-224-5p ; hsa-mir-185-5p ; hsa-mir-137 ; hsa-mir-216a-5p ; hsa-mir-330-3p ; hsa-mir-608 ; hsa-mir-29b-3p ; hsa-mir-29c-3p ; hsa-mir-29a-3p ; hsa-mir-195-5p ; hsa-mir-375 ; hsa-mir-1-3p ; hsa-mir-93-3p ; hsa-mir-484 ; hsa-mir-106b-5p ; hsa-mir-133b ; hsa-mir-204-5p ; hsa-mir-20a-3p ; hsa-mir-1207-3p ; hsa-mir-3914 ; hsa-mir-3591-3p ; hsa-mir-21-3p ; hsa-mir-107 ; hsa-mir-30c-5p
Nearest miRNA
hsa-mir-12136/Upstream/1069736; hsa-mir-101-1/Downstream/208071;
Nearest TSS
ENST00000473358/Upstream/4871; ENST00000606754/Downstream/42445;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/4632, chr1-CpG: 35/Downstream/61859
Upstream sequence
AAGCAAGGGTGTCAGGCCTCAGGTATGCagtatagtctgtggacccatcagcataagtgtcacctgggagctcattagaactatcaggattcatcccagt
Downstream sequence
tccccacatgatttttatgtgtattaaggcttgaagcacCCTCTTCAGGACTGCTAGAGTGATGTCTCAAATTTCGGAAACAATGTGAATGCTTTATTTC
Target sequence
cttactgacccagaatcttattttaataaga
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate