Basic Information
VIS ID
TVIS30014476
Fusion event
HIV-HNRNPR integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.12
Reference genome
GRCh37/hg19
Start
23637910/23311417 (Hg38)
End
23637858/23311417 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
HNRNPR
miRNAs that regulate target gene
hsa-mir-18a-5p ; hsa-mir-940 ; hsa-mir-130b-5p ; hsa-mir-615-3p ; hsa-mir-192-3p ; hsa-mir-4735-5p ; hsa-mir-32-3p ; hsa-mir-6505-5p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-510-3p ; hsa-mir-4452 ; hsa-mir-183-3p ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-2052 ; hsa-mir-4307 ; hsa-mir-7849-3p ; hsa-mir-33a-3p ; hsa-mir-1197 ; hsa-mir-203a-3p ; hsa-mir-409-3p ; hsa-mir-5096 ; hsa-mir-197-3p ; hsa-mir-627-3p ; hsa-mir-1250-3p ; hsa-mir-6750-3p
Nearest miRNA
hsa-mir-12136/Upstream/267045; hsa-mir-101-1/Downstream/617653;
Nearest TSS
ENST00000473358/Upstream/4785; ENST00000518821/Downstream/476;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/93673, chr1-CpG: 127/Downstream/32335
Upstream sequence
ATAGCCTATAAAAAATTAGAAAAATTATTTTACAACGATATAAAACTGTATTTTGTTTTATATAGTATGTAAGCTATTATACTTGTGTAATTTAATACAC
Downstream sequence
TTAACAATTTACTTCACAATTATTTTAAATGGCAAAAGGTGAATCTAGCCAGAAAGTTAAACACAAACACACAAAGAAAATACGTTTCCCTTGACCTTAT
Target sequence
TATTTTGTTTTATATAGTATGTAAGCTATTATACTTGTGTAATTTAATACAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate