Basic Information
VIS ID
TVIS30014479
Fusion event
HIV-MACO1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.11
Reference genome
GRCh37/hg19
Start
25774533/25448042 (Hg38)
End
25774559/25448042 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
MACO1
miRNAs that regulate target gene
hsa-mir-4446-5p ; hsa-mir-3679-3p ; hsa-mir-6832-3p ; hsa-mir-627-3p
Nearest miRNA
hsa-mir-12136/Upstream/424456; hsa-mir-101-1/Downstream/458320;
Nearest TSS
ENST00000473358/Upstream/17122; ENST00000470035/Downstream/851;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/16418, chr1-CpG: 109/Downstream/95360
Upstream sequence
AGATAGTTTCGGCTTATGTTCTATTGGCGGTAGTGGTGTCCAGAGGAAAGCTGCATTATTAAAATTATTATTAGTTTGGTGCAATTACTTTTGCACCAAC
Downstream sequence
AATATTATGGTTCATCTGTGCTCCAGACAGCCTGTCTTTTAAGAATGAAGCTCTTTAGGAATGGTTTGTGAGGAGAGAGAAGACTTTTCTGTATTAAAAT
Target sequence
CTAATAGCATCAGTATATTTCTTACT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate