Basic Information
VIS ID
TVIS30014480
Fusion event
HIV-LDLRAP1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.11
Reference genome
GRCh37/hg19
Start
25886637/25560146 (Hg38)
End
25886762/25560146 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
LDLRAP1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-9-5p ; hsa-mir-615-3p ; hsa-mir-92a-3p ; hsa-mir-133a-3p
Nearest miRNA
hsa-mir-12136/Upstream/536560; hsa-mir-101-1/Downstream/346216;
Nearest TSS
ENST00000473358/Upstream/5265; ENST00000484476/Downstream/2670;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/15595, chr1-CpG: 57/Downstream/56024
Upstream sequence
GGAGTTTGCCAGGCCGAGAGAAGGGGGTGGGGTGGTGGGTGGGGAGTGCACACCAGCATGGGATTAACACACGTGCAAACGCAGAGGGGCGAAGTGAAAT
Downstream sequence
TGGCTGGGGGCCTCCACATCCCTACTCTTCCTGGCTGGGCTGCCGGAATGAGTTCATGACCCATTGAGGTTGGGGGAGAAAGGCTCCTTTCTACATCACC
Target sequence
GGTTCCCCTGGGGTGGGTGGTGAGGCAGCTTCCGTTTGCAGTGGGCCTTGAATCAGGATGTTGAGGGCCTTGAATCAGGATGTTGAGGGCCTTGAATCGGGATGTTGACAAAACGTCAGTCATTG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate