Basic Information
VIS ID
TVIS30014481
Fusion event
HIV-MAN1C1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.11
Reference genome
GRCh37/hg19
Start
25956268/25629777 (Hg38)
End
25956419/25629777 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
MAN1C1
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-93-5p ; hsa-mir-20a-5p ; hsa-mir-129-5p ; hsa-mir-8055 ; hsa-mir-3140-3p ; hsa-mir-3663-3p ; hsa-mir-552-3p ; hsa-mir-6885-3p ; hsa-mir-6769b-5p ; hsa-mir-6769a-5p ; hsa-mir-6871-5p ; hsa-mir-1273e ; hsa-mir-146a-5p ; hsa-mir-146b-5p ; hsa-mir-3689d ; hsa-mir-377-5p ; hsa-mir-455-3p ; hsa-mir-6086 ; hsa-mir-6134 ; hsa-mir-6499-3p ; hsa-mir-6516-5p ; hsa-mir-665 ; hsa-mir-6807-5p ; hsa-mir-6840-3p ; hsa-mir-6851-5p ; hsa-mir-6880-5p ; hsa-mir-7153-5p ; hsa-mir-7847-3p
Nearest miRNA
hsa-mir-12136/Upstream/606191; hsa-mir-101-1/Downstream/276585;
Nearest TSS
ENST00000473358/Upstream/11927; ENST00000473891/Downstream/29334;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/11496, chr1-CpG: 16/Downstream/141636
Upstream sequence
cccaaagtgctgggattacaggtgtgagccactgcacccagccatttgcccactttttaattgattttttttttttctgatttgagtttcttgtggtttt
Downstream sequence
cattcgcttttggggtcttagtcatgaagtctttgcctaggccaatgtccagaagagtttttctgatgttatctttagaattcttatggtttcaggtctt
Target sequence
tagacactagttctttgttggatatatagtatgcaaatattttctcccattatgtgcattgtctttttactctgatgattattacttttgctgtgcagaaactttttagtttaacgagatcccatttattgatctatttttgtttttattg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate