Basic Information
VIS ID
TVIS30014482
Fusion event
HIV-chr1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.11
Reference genome
GRCh37/hg19
Start
26112722/25786231 (Hg38)
End
26112994/25786231 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1A
Nearest miRNA
hsa-mir-12136/Upstream/762645; hsa-mir-101-1/Downstream/120131;
Nearest TSS
ENST00000473358/Upstream/5517; ENST00000494537/Downstream/13945;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/14615, chr1-CpG: 35/Downstream/14093
Nearby gene
MAN1C1(No orient, 1464)
Upstream sequence
aatctgcttttgcacttaactgtacattgtgaacctctttccatgtcaacaaatacatgtttatctcatcgctgtacgtgcttgtggagtattccattgt
Downstream sequence
TGTTTCCAGATCCTGCTGTGGCTCCTTTCCATGtggcctggcctgggtcacatgcccgccccagccaagggcagagccaggcatcttggcttggcagacc
Target sequence
gtgctgtagcctactttgctgatctaagcccctgttgccaggcatttgggtttgtgtccatctgggattttagttacaaatcacagaaaccaactctgtcaacttaagcacagaaagggatttactgaaatgccatggggtggcttatggaatctcaggaaggagtaaacagccaaacctCAATAAGGGCTAGAAAGAGGACTTGGCCAGGGACCCCTTCAAGAACCAGGGAAGCCTCTCTAGGCACCACCATCA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate