Basic Information
VIS ID
TVIS30014486
Fusion event
HIV-RPS6KA1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.11
Reference genome
GRCh37/hg19
Start
26889261/26562770 (Hg38)
End
26889117/26562770 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
RPS6KA1
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-mir-193b-3p ; hsa-mir-769-3p ; hsa-mir-450b-3p ; hsa-mir-4769-5p ; hsa-mir-4654 ; hsa-mir-6766-5p ; hsa-mir-6756-5p ; hsa-mir-638 ; hsa-mir-4713-3p ; hsa-mir-6502-5p ; hsa-mir-1301-5p ; hsa-mir-520f-5p ; hsa-mir-4509 ; hsa-mir-4744 ; hsa-mir-186-3p ; hsa-mir-4733-5p ; hsa-mir-4429 ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-320a
Nearest miRNA
hsa-mir-12136/Upstream/8177; hsa-mir-101-1/Downstream/4176386;
Nearest TSS
ENST00000473358/Upstream/5727; ENST00000530305/Downstream/8459;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/32577, chr1-CpG: 119/Downstream/57583
Upstream sequence
GAGATAATGTTTTAGGGTGCATCTGATCAGACAACATGGGGGTTAAGAATGCAGGCTATGAATCCACCTGGCTGAGTCCAGGTCTTGGTGTATGAGGTTG
Downstream sequence
TTAACTTGTTTTCACATAGTACCCAGTCCATAGACACATTTTTCTCCTATTGTCCtttttttttttttttttttttttttttggagatagagtcttgctc
Target sequence
AGTGGATTAAAGCCCAAAACAGTAGCATTAGCTTCTCTCTGCATGAGATAATGTTTTAGGGTGCATCTGATCAGACAACATGGGGGTTAAGAATGCAGGCTATGAATCCACCTGGCTGAGTCCAGGTCTTGGTGTATGAGGTTG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate