Basic Information
VIS ID
TVIS30014490
Fusion event
HIV-EYA3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p35.3
Reference genome
GRCh37/hg19
Start
28401337/28074826 (Hg38)
End
28401454/28074826 (Hg38)
Orient
+
Location type
Intronic
Target gene
EYA3
miRNAs that regulate target gene
hsa-mir-30b-5p ; hsa-let-7c-5p ; hsa-mir-708-5p ; hsa-mir-2467-3p ; hsa-mir-1827 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-6856-5p ; hsa-mir-6758-5p
Nearest miRNA
hsa-mir-12136/Upstream/1520233; hsa-mir-101-1/Downstream/2664330;
Nearest TSS
ENST00000473358/Upstream/16739; ENST00000465645/Downstream/13738;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/114499, chr1-CpG: 23/Downstream/13761
Upstream sequence
tggaccatacttaagtggttttttgcatgctttgtaataacagtctcttgaaaactaaacattttaaataaggtaatgtgacaactcgaaaaatcagatt
Downstream sequence
gtcactaaagtctctgctgttcatttgtgatcagctaatgactgggcagagacttccttaaatgcttaaaaccagtataagactcagtgtgtattgacag
Target sequence
cttcccctaccaggtatttgttgttattactgtttactgttgttactgtttattgttgtttcttttagtgactttcctgaactaattatctaaaatattaattttctatcatatgtg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate