Basic Information
VIS ID
TVIS30014503
Fusion event
HIV-KIAA0319L integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p34.3
Reference genome
GRCh37/hg19
Start
35949295/35483694 (Hg38)
End
35949387/35483694 (Hg38)
Orient
+
Location type
Intronic
Target gene
KIAA0319L
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-128-3p ; hsa-mir-423-3p ; hsa-mir-432-5p ; hsa-mir-218-5p ; hsa-mir-5689 ; hsa-mir-571 ; hsa-mir-219a-1-3p ; hsa-mir-129-5p ; hsa-mir-6805-3p ; hsa-mir-5691 ; hsa-mir-431-5p ; hsa-mir-4294 ; hsa-mir-3194-3p ; hsa-mir-924
Nearest miRNA
hsa-mir-12136/Upstream/814000; hsa-mir-101-1/Downstream/1677869;
Nearest TSS
ENST00000473358/Upstream/12788; ENST00000459931/Downstream/23173;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/214440, chr1-CpG: 95/Downstream/73385
Upstream sequence
accaataccactgccttgattactgtggctatacagtaagtcttctagctagatagtttaagtcctccaactctattgttctttttcaaaatcattttga
Downstream sequence
gaaattcattctctcacagttctggaggccagaagtctgaaatcaaggtgttggcagggccatactgcctctgaaggccctagaggagaatctttctttg
Target sequence
tcattctagatccCAATCTGTATAACATGGTtatatttgtttcctagagctgccataatgaattactataaactttgtggcttaaaacaata
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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