Basic Information
VIS ID
TVIS30014512
Fusion event
HIV-MACF1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p34.3
Reference genome
GRCh37/hg19
Start
39867517/39401845 (Hg38)
End
39867411/39401845 (Hg38)
Orient
-
Location type
Intronic
Target gene
MACF1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-16-5p ; hsa-mir-296-3p ; hsa-mir-615-3p ; hsa-mir-125a-5p ; hsa-mir-222-3p ; hsa-mir-30d-5p ; hsa-mir-92a-3p ; hsa-let-7e-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p
Nearest miRNA
hsa-mir-12136/Upstream/1312516; hsa-mir-101-1/Downstream/1352510;
Nearest TSS
ENST00000473358/Upstream/70707; ENST00000641012/Downstream/7658;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/295658, chr1-CpG: 115/Downstream/6501
Upstream sequence
AATTCATTCCCAAAGGATAAGCTCTGGTTTTGGTCTAATTCTTTAAATTCATACCTAAGCTGTTTGTTTCTTTGTCATCAATGATAAGAATTTTCCTTAG
Downstream sequence
TAACGAAATGAAAGAGATGGTTTTTAGAAATCTCTTCTCTCTGTATTATTTATTCTGCCTTCTTTTCTAATATTGAGGAGCAGGggctggacgcagtggc
Target sequence
TCTTGCAATTCATTCCCAAAGGATAAGCTCTGGTTTTGGTCTAATTCTTTAAATTCATACCTAAGCTGTTTGTTTCTTTGTCATCAATGATAAGAATTTTCCTTAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate