Basic Information
VIS ID
TVIS30014514
Fusion event
HIV-NFYC integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p34.2
Reference genome
GRCh37/hg19
Start
41162805/40697133 (Hg38)
End
41162944/40697133 (Hg38)
Orient
+
Location type
Intronic
Target gene
NFYC
miRNAs that regulate target gene
hsa-mir-33a-5p ; hsa-mir-155-5p ; hsa-mir-221-3p
Nearest miRNA
hsa-mir-12136/Upstream/2607804; hsa-mir-101-1/Downstream/57222;
Nearest TSS
ENST00000473358/Upstream/4843; ENST00000531464/Downstream/12224;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/4830, chr1-CpG: 128/Downstream/86285
Upstream sequence
tcagaccaagggaagagttctgtctctgcagtgcatttaccctctgtgctggagcaggttcttaacttgtttcttcttctgtaaaataacgacaataata
Downstream sequence
CCTTGATGAGGAGGGGTGAGGCCTTTTGTAATTGTCTGCTCTGCAATATACAGTAAGATTTCCAAATGGGAGAGCAACCACTTGACATGAAGTAACCTAA
Target sequence
cctacctgtagggtaattatgagaaatgaatataatagcgtgtggtagatgcctatcacttagtggaccttaataagtgggagAACACATTTTCATTTTGGAACAGCATGAAATCTGTCCTTTCAGCCCGTTACAGCTT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate