Basic Information
VIS ID
TVIS30014523
Fusion event
HIV-NRDC integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p32.3
Reference genome
GRCh37/hg19
Start
52329878/51864206 (Hg38)
End
52329939/51864206 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1B
Target gene
NRDC
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-615-3p ; hsa-mir-181d-5p ; hsa-mir-125b-5p ; hsa-mir-181b-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-12136/Upstream/27804; hsa-mir-101-1/Downstream/2189873;
Nearest TSS
ENST00000473358/Upstream/23752; ENST00000425802/Downstream/13834;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/134057, chr1-CpG: 56/Downstream/14300
Upstream sequence
caaagatcggtttctactgaatgcatatcacttttttgcaccatggaaagtggaaaaaccctaagttgaaccaacataaattagggaccatctgtactca
Downstream sequence
ttttcaaagataaggtatgtaaaatctcattacaaatcagatttaacagatgaactgactgatgaacacttaattttgatcccaataaagcaaaatgtta
Target sequence
tagactgctattagtatttcaatattaatatattggcggtacctagctatgtggaaagaca
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate