Basic Information
VIS ID
TVIS30014527
Fusion event
HIV-TUT4 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p32.3
Reference genome
GRCh37/hg19
Start
52904006/52438334 (Hg38)
End
52903797/52438334 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA1B
Target gene
TUT4
miRNAs that regulate target gene
hsa-mir-196a-5p ; hsa-let-7b-5p ; hsa-mir-26a-5p ; hsa-mir-4791 ; hsa-mir-3201 ; hsa-mir-203a-3p ; hsa-mir-216b-5p
Nearest miRNA
hsa-mir-12136/Upstream/601932; hsa-mir-101-1/Downstream/1615745;
Nearest TSS
ENST00000473358/Upstream/1079; ENST00000607321/Downstream/8294;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/33701, chr1-CpG: 115/Downstream/114252
Upstream sequence
CAGTCTTTCATGTAGTGGCCTATTTTTCCACACACACGGCAACATCTATCATTGGGAGCCAGTTCTCCATCTGTTAATACTCTGGAATCAAAGAAGTACT
Downstream sequence
CCTAGGGAGAAAATGCAATTTTACTAGGAGGAATCACTATAAAACTTTTGAATCCAAATGGAAAGAAGACCAAGATGCAAACATGGTTTATTTTTACAAA
Target sequence
CTTTCTCAGTTAAACATTTCTGAACATAATTATAGCTACAAATTGGCCTCTCATTTATTTTCCTCAAAATGTTGATATATATTCATTTGCCAACCTTTTCCTTTTAGGGCAGTCTTTCATGTAGTGGCCTATTTTTCCACACACACGGCAACATCTATCATTGGGAGCCAGTTCTCCATCTGTTAATACTCTGGAATCAAAGAAGTACT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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