Basic Information
VIS ID
TVIS30014529
Fusion event
HIV-TUT4 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p32.3
Reference genome
GRCh37/hg19
Start
52956520/52490848 (Hg38)
End
52956683/52490848 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1B
Target gene
TUT4
miRNAs that regulate target gene
hsa-mir-196a-5p ; hsa-let-7b-5p ; hsa-mir-26a-5p ; hsa-mir-4791 ; hsa-mir-3201 ; hsa-mir-203a-3p ; hsa-mir-216b-5p
Nearest miRNA
hsa-mir-12136/Upstream/654446; hsa-mir-101-1/Downstream/1563231;
Nearest TSS
ENST00000473358/Upstream/22358; ENST00000607321/Downstream/35082;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/86215, chr1-CpG: 115/Downstream/61738
Upstream sequence
CACCACAACAGGAACTTTAGCGTGAAAATCAGATTCCACATCTACATATAATACTAATAAGGAAAAAAAAAAGTAAGCTAATGTCAACATCTCTAAAATA
Downstream sequence
ATACTGTCCAAAAATTATAATCACCTTAAGAAAGGTCTTAACATCCCTAAAAGTTTTAATATTTCCAAGTAAGTAGATAATCTAGTCAAAGTTGTTAAAC
Target sequence
CGTACTCTACAGTAAACATTAAGTAACAGTTTCCTTCTGAAAATTATTCTCATTGCTTCTGTGGGATAATCCACTCTTCTCATTATGAGCACCAACCCAGCGAAATCTCTTACCTCTCCTGGTGTCATTTGCTGTATATCACAAACCACAGGTACAGCCCCAA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate