Basic Information
VIS ID
TVIS30014533
Fusion event
HIV-PDE4B integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
GRCh37/hg19
Start
66812170/66346487 (Hg38)
End
66811702/66346487 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
PDE4B
miRNAs that regulate target gene
hsa-mir-374a-5p ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-330-5p ; hsa-mir-34a-3p
Nearest miRNA
hsa-mir-101-1/Upstream/1287979; hsa-mir-11399/Downstream/281953;
Nearest TSS
ENST00000473358/Upstream/14298; ENST00000524999/Downstream/7895;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/553252, chr1-CpG: 35/Downstream/186558
Upstream sequence
AAACCAAAGAAGCATGAATGGATAGTTACCAACAGCTGGATTTCTCCAAATAGACTCTTTTTTTACGGTTTAACTTAAGCATAAGACCATTTTGAGTTAT
Downstream sequence
GGTGCTTTTCATTTGACTTGCTTCATCTATCTTTCTGGCAATTCTTGTTTACGCTCCTTAGACTGGTGAATAATCTAAATGTCAACCAGAGAGTCTGAAC
Target sequence
CATCCTGTGGACAAGAATCTAAGCCCTTTGGAGACTAGCAATGGCTATTCCACACTCTCTGGGGAGCCTATTTATGAGCACATGTGTTTGTAATTCAGCCACTCTCCATATCTGTTGGAGAATAGCAGCCTAATTATCTGCCATCATTTGGTTATGTTTTTCATTCCTGGCATATTGGTGACACTCCTCTCACCTGAGCCACATATTCAATTAATTCATATGTGTTACCACATTGATCTTAACTGTGAAAATCTG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate