Basic Information
VIS ID
TVIS30014535
Fusion event
HIV-MIER1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
GRCh37/hg19
Start
67404598/66938915 (Hg38)
End
67404735/66938915 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
MIER1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-30e-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-580-3p ; hsa-mir-4324 ; hsa-mir-4251 ; hsa-mir-20b-3p ; hsa-mir-3137 ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-3686 ; hsa-mir-190a-3p ; hsa-mir-298 ; hsa-mir-338-3p ; hsa-mir-4530 ; hsa-mir-922 ; hsa-mir-5586-5p ; hsa-mir-410-3p ; hsa-mir-5197-3p ; hsa-mir-450b-5p ; hsa-mir-4511 ; hsa-mir-4696
Nearest miRNA
hsa-mir-101-1/Upstream/310398; hsa-mir-11399/Downstream/1244603;
Nearest TSS
ENST00000473358/Upstream/6263; ENST00000493357/Downstream/19996;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/8115, chr1-CpG: 59/Downstream/114947
Upstream sequence
TAAGAATTTAACAGAAAAAGTAGGACCTTTGAAAAAGTGTGCCACAAAAGAATGAGTCACCATATGGAATCTAGAATCCCATACTTACTACAATTACATA
Downstream sequence
ACTGCAAGATCCCTATCTTTCCTTTGCTAGTGCTTTTGGCCTCCCACCATCTGTATTTTCTAATGGGCATGAAATAGATACTTCTGAATGAATTGGTGAA
Target sequence
ATATGTACAGTTTTAAAAACAAATTTTAATACTTTATAGGAATTTGTCTTAGACACATTGTTTTTGAAAAATAGAGAATTTCCCTCTTTTCTGTTTTCTTCTTGCCTCTCTTCCCCATTACTTAGCAGAAAGAAAAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate