Basic Information
VIS ID
TVIS30014536
Fusion event
HIV-IL12RB2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
GRCh37/hg19
Start
67787986/67322303 (Hg38)
End
67787871/67322303 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
IL12RB2
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-625-5p ; hsa-mir-3180-5p ; hsa-mir-493-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-200b-5p ; hsa-mir-200a-5p ; hsa-mir-129-5p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-151a-3p
Nearest miRNA
hsa-mir-101-1/Upstream/693786; hsa-mir-11399/Downstream/861215;
Nearest TSS
ENST00000473358/Upstream/14430; ENST00000441640/Downstream/4466;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/187271, chr1-CpG: 139/Downstream/107149
Upstream sequence
AAGCTACAGCCTCCTAAAAAGAAAGAAGAGATGTCTTTTTAGACTTATGCAGCCCAGGATGACTACACAGAGTTGAACAGCACCTCTCGTCCTATCTAAC
Downstream sequence
TTAATGCCTCCCAAAATAGTTCTTCCATCCATGCTCACCCGGACCACTGGTTCTCATACTTAACAGAAGGTAAAAGAAAACATTGATCATACTTACTATC
Target sequence
AGGAGAATATGTTTAAAGCTACAGCCTCCTAAAAAGAAAGAAGAGATGTCTTTTTAGACTTATGCAGCCCAGGATGACTACACAGAGTTGAACAGCACCTCTCGTCCTATCTAAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate