Basic Information
VIS ID
TVIS30014538
Fusion event
HIV-FUBP1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
78431326/77965642 (Hg38)
End
78431267/77965642 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
FUBP1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-615-3p ; hsa-mir-324-3p ; hsa-mir-222-3p ; hsa-mir-22-3p ; hsa-mir-218-5p ; hsa-let-7i-3p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-4787-3p ; hsa-mir-1277-5p ; hsa-mir-16-5p
Nearest miRNA
hsa-mir-101-1/Upstream/905440; hsa-mir-11399/Downstream/7168152;
Nearest TSS
ENST00000473358/Upstream/4857; ENST00000426517/Downstream/13444;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/76654, chr1-CpG: 23/Downstream/12977
Nearest cancer related gene
FUBP1(OG, No orient, 0)
Upstream sequence
ATTTATTTACATTTTTAAACTACCATTTTGCTTACTCATATGCTACAAttattcattcaacaaatatttaaatatcaactatgtgcaggtgctattctag
Downstream sequence
gtaatggggtaatagcactcaaagaaacagggttcctgctagagtggcttcatttcattaaataagtaaaaataacatgtcaaatgaataacacattatt
Target sequence
GCTACAAttattcattcaacaaatatttaaatatcaactatgtgcaggtgctattctag
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate