Basic Information
VIS ID
TVIS30014542
Fusion event
HIV-chr1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
93439116/92973559 (Hg38)
End
93439442/92973559 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1D
Nearest miRNA
hsa-mir-101-1/Upstream/6615872; hsa-mir-11399/Downstream/873273;
Nearest TSS
ENST00000473358/Upstream/12037; ENST00000474314/Downstream/105676;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/11362, chr1-CpG: 45/Downstream/105442
Nearby gene
RNU6-970P(-3849) ; RN7SL692P(+1268) ;
Upstream sequence
TGTCCTATTCCAGTGTGGTCTCATTTTGTTCCAAAGGTGGTTTTCTTTTTTAAAAACAGAAGTATTGACAGTTGGTCCCATGTTATATTTTTCCGCTTTA
Downstream sequence
TCCCCACCATGGGGCTGAAATGAAGAGCTGAAGGTCTCATAGGCAATTCTGGGCCACATTCAGTCTTGTTGAGACCTCTTTGGTGTGATTTGTATgaatt
Target sequence
CAGACTCTAACAAAGTTCTACAGATATGAAAGTCTGGTGACATTTCCCTTCTCTTTATAAAGTGTGGATTTCACAGAACCCACTCCCTGTCAAGGCCATCTGGGGAAGTGTAGAATCTTTTATCTCTCTAGGCAAAAGGGTTTATCTGTTTTACTTCCTTCTTTTAAGCTGAGGACCTTCTGAGGTAGTTTCTTTAATAAGTAAATTACTTTCTTCCCCTGTCTTACCTGACTGTGTTGATAGCAGAAGTGAGGG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate