Basic Information
VIS ID
TVIS30014549
Fusion event
HIV-CDC14A integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
100863968/100398412 (Hg38)
End
100863851/100398412 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1E
Target gene
CDC14A
miRNAs that regulate target gene
hsa-mir-503-5p ; hsa-mir-424-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-628-3p ; hsa-mir-630 ; hsa-mir-301a-3p
Nearest miRNA
hsa-mir-101-1/Upstream/117104; hsa-mir-11399/Downstream/7498811;
Nearest TSS
ENST00000473358/Upstream/35251; ENST00000469387/Downstream/25320;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/45069, chr1-CpG: 146/Downstream/140600
Upstream sequence
ACCTCCCTGATGATCGGACAGCTACTTCCCCTCTTTCTGTCTGCCCATCTTCCTCTTGTCCATCATATTTTTCACTTAAATACTTCCTTGGCTCAGTAAC
Downstream sequence
AACACTCATATGGTTGTTAATCTGATTATTGCTTAGTATAATTCACTGGAAGGTAGGAGTATATTTCTCTCCAAGGATGTTATTTTAAGGGAATATTTTG
Target sequence
CGTAGACCCTTTGGGCTACCTCCCTGATGATCGGACAGCTACTTCCCCTCTTTCTGTCTGCCCATCTTCCTCTTGTCCATCATATTTTTCACTTAAATACTTCCTTGGCTCAGTAAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate