Basic Information
VIS ID
TVIS30014565
Fusion event
HIV-RAP1A integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
112117465/111574843 (Hg38)
End
112117400/111574843 (Hg38)
Orient
-
Location type
Intronic
Target gene
RAP1A
miRNAs that regulate target gene
hsa-mir-337-3p ; hsa-let-7e-5p ; hsa-mir-3591-5p ; hsa-mir-1273e ; hsa-mir-4473 ; hsa-mir-4671-3p ; hsa-mir-636 ; hsa-mir-135a-3p ; hsa-mir-302c-3p ; hsa-mir-512-3p ; hsa-mir-520f-3p ; hsa-mir-4470 ; hsa-mir-759 ; hsa-mir-4761-5p ; hsa-mir-5000-5p ; hsa-mir-4735-3p ; hsa-mir-18b-5p ; hsa-mir-18a-5p ; hsa-mir-551b-5p ; hsa-mir-4799-5p ; hsa-mir-8059 ; hsa-mir-4471 ; hsa-mir-6837-3p ; hsa-mir-6754-3p ; hsa-mir-412-3p ; hsa-mir-6715a-3p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-6822-5p ; hsa-mir-6750-5p ; hsa-mir-1277-5p ; hsa-mir-10a-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-203a-3p ; hsa-mir-203a-5p ; hsa-mir-1268a ; hsa-mir-1268b ; hsa-mir-1272 ; hsa-mir-340-3p ; hsa-mir-4486 ; hsa-mir-4684-5p ; hsa-mir-548c-3p ; hsa-mir-585-3p ; hsa-mir-6771-3p ; hsa-mir-6827-3p
Nearest miRNA
hsa-mir-101-1/Upstream/1975876; hsa-mir-11399/Downstream/886927;
Nearest TSS
ENST00000473358/Upstream/10881; ENST00000433097/Downstream/33475;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/58875, chr1-CpG: 59/Downstream/44739
Nearest cancer related gene
RAP1A(TSG, No orient, 0)
Upstream sequence
TAGTAAATAGTTGGAACTGACCTGAAACAAGTGTAGTACCAGATAGGTTTTTGGGAAGCCAAATTCAGGGGCTGGTTTTGTTTGGAAGGCAGTGGCTCTG
Downstream sequence
CTATACTGTTTTTTTGAATTTGGCAAGAAATAATTATGTGATCTGTGGCTACACAAAAAAATGAATTGCTATAGCAGTAGATAGTGTAAGCATATAGACT
Target sequence
GTACCAGATAGGTTTTTGGGAAGCCAAATTCAGGGGCTGGTTTTGTTTGGAAGGCAGTGGCTCTG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate