Basic Information
VIS ID
TVIS30014571
Fusion event
HIV-WDR3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p12
Reference genome
GRCh37/hg19
Start
118475599/117932976 (Hg38)
End
118475563/117932976 (Hg38)
Orient
-
Location type
Intronic
Target gene
WDR3
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-mir-8485 ; hsa-mir-223-5p ; hsa-mir-496 ; hsa-mir-466 ; hsa-mir-3941 ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-6833-3p ; hsa-mir-6809-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-1229-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-6862-3p ; hsa-mir-6784-3p ; hsa-mir-6511b-3p ; hsa-mir-6511a-3p ; hsa-mir-6832-3p ; hsa-mir-6795-3p ; hsa-mir-6887-3p ; hsa-mir-493-5p ; hsa-mir-511-3p
Nearest miRNA
hsa-mir-101-1/Upstream/838248; hsa-mir-1182/Downstream/27917611;
Nearest TSS
ENST00000473358/Upstream/3201; ENST00000423984/Downstream/31834;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/2879, chr1-CpG: 23/Downstream/252217
Upstream sequence
TACATGCTTTTAATGACATGATCAACAGTTGGTGTTGTTCTggcgcagtggctaacacctgtaatcccagcactttgggaggccgtggcggatggatcac
Downstream sequence
ttgaggtgaggctttcgagacgagcctggccaatatggtgaaaccccatctctactaaaaaaaaaaaaaaaaaaaaaattagccgggtatggtggcacat
Target sequence
tcccagcactttgggaggccgtggcggatggatcac
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate