Basic Information
VIS ID
TVIS30014573
Fusion event
HIV-PDE4DIP integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
144924607/148959880 (Hg38)
End
144924468/148959880 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
PDE4DIP
miRNAs that regulate target gene
hsa-mir-505-3p ; hsa-mir-92a-3p ; hsa-let-7a-5p ; hsa-mir-493-3p ; hsa-mir-620 ; hsa-mir-1270 ; hsa-mir-4531 ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-539-5p ; hsa-mir-432-5p ; hsa-mir-3976 ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-3121-3p ; hsa-mir-452-3p ; hsa-mir-582-5p ; hsa-mir-3618 ; hsa-mir-139-5p ; hsa-mir-670-3p ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-6513-3p ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-3614-3p
Nearest miRNA
hsa-mir-101-1/Upstream/571517; hsa-mir-1182/Downstream/1532465;
Nearest TSS
ENST00000473358/Upstream/7539; ENST00000496263/Downstream/2530;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/6731, chr1-CpG: 98/Downstream/143032
Upstream sequence
agtttataaagcaaatgtgacaaaatatttgcaactggtaaatctgggtaaagggtatatgggagttcttggtatttctcttataacatctctgtacgtt
Downstream sequence
tgaaattatttcaaaataaaaaGAGaaaaattaaaataaatttaaaataGATGTGCCTAAAGGCAGATTTATAGCATAAGCACAGATAAATAATCCATAG
Target sequence
aatttttaaaaaatactgtgcaaatacagacagtgggagagtttataaagcaaatgtgacaaaatatttgcaactggtaaatctgggtaaagggtatatgggagttcttggtatttctcttataacatctctgtacgtt
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate