Basic Information
VIS ID
TVIS30014576
Fusion event
HIV-VPS45 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
150058428/150086342 (Hg38)
End
150058391/150086342 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
VPS45
miRNAs that regulate target gene
hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-34a-5p ; hsa-mir-186-5p ; hsa-mir-100-5p ; hsa-mir-99a-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-186-3p ; hsa-mir-6782-3p ; hsa-mir-4429 ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-320a
Nearest miRNA
hsa-mir-101-1/Upstream/1697979; hsa-mir-1182/Downstream/406003;
Nearest TSS
ENST00000473358/Upstream/8607; ENST00000472756/Downstream/5663;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/18584, chr1-CpG: 190/Downstream/63163
Upstream sequence
cttttgtctataaagggggaaaaataatagtacttacctcagaattgttgtgagagtgcaatgagctaatacatgtaaaacacttatggtacttggtact
Downstream sequence
tacagctttcaagaaatattaactaCCAACATTAAGAGTATTATTATTTGATGGTACATTTAATTTTCTTAATGGCATCCAAGACATGTTTTTTAGTTCA
Target sequence
agctaatacatgtaaaacacttatggtacttggtact
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate