Basic Information
VIS ID
TVIS30014578
Fusion event
HIV-VPS45 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
150092532/150120412 (Hg38)
End
150092582/150120412 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
VPS45
miRNAs that regulate target gene
hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-34a-5p ; hsa-mir-186-5p ; hsa-mir-100-5p ; hsa-mir-99a-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-186-3p ; hsa-mir-6782-3p ; hsa-mir-4429 ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-320a
Nearest miRNA
hsa-mir-101-1/Upstream/1732049; hsa-mir-1182/Downstream/371933;
Nearest TSS
ENST00000473358/Upstream/11237; ENST00000492304/Downstream/28771;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/52654, chr1-CpG: 190/Downstream/29093
Upstream sequence
TTTATTTCTGACATATATCAAGATCACTTTTACTGTAAATTGAAACAAAATCTTAGTTGTAAACAAAACTTAAAAATAAAGAAGAGAAAGCAATTATTCC
Downstream sequence
CAGAGCCTTTGTATAAGTAAGCTCGTCATCTTAAGCAAGGAGTCACCTGAAGATATAGGTCCCTTAGATCCTAATAGGAAATATACATTAGTTTAATCTG
Target sequence
TTTCCTCCCTAGTATATTTCCAAAAATGAACATAATTTTTAGTGTAAGAA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate