Basic Information
VIS ID
TVIS30014583
Fusion event
HIV-SETDB1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
150916189/150943713 (Hg38)
End
150916325/150943713 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
SETDB1
miRNAs that regulate target gene
hsa-mir-296-3p ; hsa-mir-324-3p ; hsa-mir-152-3p ; hsa-mir-92a-3p ; hsa-mir-1260b ; hsa-mir-29a-3p ; hsa-let-7c-5p ; hsa-mir-1296-5p ; hsa-mir-2909 ; hsa-mir-3689d ; hsa-mir-4286 ; hsa-mir-4434 ; hsa-mir-4443 ; hsa-mir-4512 ; hsa-mir-4516 ; hsa-mir-4531 ; hsa-mir-5703 ; hsa-mir-6134 ; hsa-mir-6515-5p ; hsa-mir-6851-5p ; hsa-mir-6880-5p ; hsa-mir-6895-5p ; hsa-mir-7160-3p
Nearest miRNA
hsa-mir-101-1/Upstream/391699; hsa-mir-1182/Downstream/602083;
Nearest TSS
ENST00000473358/Upstream/15871; ENST00000528749/Downstream/17604;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/17350, chr1-CpG: 136/Downstream/30307
Nearest cancer related gene
SETDB1(OG, No orient, 0)
Upstream sequence
tgccatgagccgagattgcaccactgcaccccagcctgggcgacagaaggagactccgtctcaaaaaTATTTATATGTATATGTGTTTTTTTAAAAGTAG
Downstream sequence
AAATAATTTCTGTGGATCATGTTAAATATCATAACCCCCAGATCTTTCTGCTGTCACTCTTCTTTTATAGGTTTCTCATTTTCTTTGATGATGGCTATGC
Target sequence
GGAGGTATTGGTTAAATTAAGGGAGAACTCCTAACTCTCAAGTTGAGAAGAAAGAAAAACAGGAAGAAAGTAGTGGACTGGATTGTCTTCCCTGGAGTGCATCGTGTTGTGATCCAGAGAAGTAGAAGCTATGATA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate