VISDB - VIS Detail

Basic Information

VIS ID

TVIS30014586

Fusion event

HIV-POGZ integration

Validated

Yes

Detection method

LM PCR

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

24968937

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr1

Cytoband

q21.3

Reference genome

GRCh37/hg19

Start

151387473/151414997 (Hg38)

End

151387335/151414997 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA1F

Target gene

POGZ

miRNAs that regulate target gene

hsa-mir-130b-3p ; hsa-mir-9-5p ; hsa-mir-221-3p ; hsa-mir-34a-5p ; hsa-mir-19b-3p ; hsa-mir-324-3p ; hsa-mir-27b-3p ; hsa-mir-92a-3p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-212-5p ; hsa-mir-3153 ; hsa-mir-6733-5p ; hsa-mir-6739-5p ; hsa-mir-186-3p ; hsa-mir-580-5p ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-2110 ; hsa-mir-432-3p ; hsa-mir-580-3p ; hsa-mir-6780b-5p ; hsa-mir-4694-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-1193 ; hsa-mir-3134 ; hsa-mir-5681a ; hsa-mir-8057 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-4448 ; hsa-mir-3189-3p ; hsa-mir-6736-3p ; hsa-mir-6863 ; hsa-mir-6755-3p ; hsa-mir-548aw ; hsa-mir-513b-5p ; hsa-mir-19a-3p ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-125b-2-3p ; hsa-mir-4457 ; hsa-mir-3613-3p ; hsa-mir-454-3p ; hsa-mir-3666 ; hsa-mir-4295 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130a-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-4307

Nearest miRNA

hsa-mir-101-1/Upstream/862983; hsa-mir-1182/Downstream/130799;

Nearest TSS

ENST00000473358/Upstream/6444; ENST00000505188/Downstream/8424;

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/14891, chr1-CpG: 112/Downstream/43753

Upstream sequence

GGGAAGGAGCTAATACAGAAAAAGATTCAAGAGGGAAAATGAATTGATTCTCCATGGTGGCTGTCCTAACTGTCCCTCTGAGCACCATCACCCTCCTTAA

Downstream sequence

CACCTAACACAATCTCCTACTTTGAGGAAATAGGCATGAACAACTGTAACTTCTGCTGCTTGTTTTCCAAATTATGGAAGGATAGATCTCTTGTACCTTC

Target sequence

AGAGATCTCTGGTAACCTTTGACACATCAGTTCTACAGGGGAAGGAGCTAATACAGAAAAAGATTCAAGAGGGAAAATGAATTGATTCTCCATGGTGGCTGTCCTAACTGTCCCTCTGAGCACCATCACCCTCCTTAA

Reference

Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.