Basic Information
VIS ID
TVIS30014592
Fusion event
HIV-C1orf43 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
154185506/154213030 (Hg38)
End
154185555/154213030 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
C1orf43
miRNAs that regulate target gene
hsa-mir-340-5p ; hsa-mir-1226-3p ; hsa-mir-296-3p ; hsa-mir-769-3p ; hsa-mir-106b-5p ; hsa-mir-15b-5p ; hsa-mir-136-3p ; hsa-mir-1185-1-3p ; hsa-mir-1185-2-3p ; hsa-mir-6083 ; hsa-mir-6868-5p ; hsa-mir-8073 ; hsa-mir-221-5p ; hsa-mir-103b ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-3074-3p ; hsa-mir-4293 ; hsa-mir-596
Nearest miRNA
hsa-mir-101-1/Upstream/19287; hsa-mir-1182/Downstream/762663;
Nearest TSS
ENST00000473358/Upstream/300; ENST00000441890/Downstream/7149;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/29580, chr1-CpG: 79/Downstream/7337
Upstream sequence
ccaaagcgttgggattacaggcatgagccactgcgcctgcccCATTCTTTAGTCTTTCTAGTTAATTCCCCAAACTTAGAAGTAGGTCTAATGAAgctgg
Downstream sequence
gcagatcacctgaggtcaggagtttgagaccagcctggccaacatggtgaaaacctgtccctactaaaaatacaaaaattaaccaggcatggtggtaggt
Target sequence
gcgcagtggctcacgcctgtaattacagcaatttgggaggccggggcag
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate